Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | IDE | P14735 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HLCS | P50747 | 6/20 | 0.53 |
| ▸ | CA12 | O43570 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CA9 | Q16790 | 4/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.42 |
| ▸ | PTPRF | P10586 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8509413 | 0.90 | TDP1 (0.57) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL487045 | 0.87 | TDP1 (0.68) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL4464825 | 0.85 | TDP1 (0.60) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL29375721 | 0.85 | TDP1 (0.70) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL2182339 | 0.85 | TDP1 (0.60) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL8508662 | 0.85 | TDP1 (0.60) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL5498960 | 0.85 | TDP1 (0.60) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL714968 | 0.84 | TDP1 (0.63) | TDP1MEN1ABL1LMNAPKM | |
| Iodide SCHEMBL2533594 | 0.83 | TDP1 (0.61) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL15020036 | 0.83 | HLCS (0.65) | TDP1MEN1ABL1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1346730-A1 | Pretargeting methods and novel pretargeting conjugates | NEORX CORPORATION (US) | 2003-09-24 | — | — | EP | disclosed |
| EP-0794788-B1 | HEPATIC-DIRECTED COMPOUNDS AND REAGENTS FOR PREPARATION THEREOF | NEORX CORP (US) | 2003-05-14 | — | — | EP | disclosed |
| US-6217869-B1 | ADMINISTERING ANTIBODY, ANTIGEN, LIGAND COMPLEX | NEORX CORPORATION | 2001-04-17 | — | — | US | disclosed |
| US-6015897-A | FOR CONJUGATION TO LIGAND/ANTILIGAND PAIR AND USE IN DELIVERY OF THERAPEUTIC OR DIAGNOSTIC AGENT TO TARGETED SITE | NEORX CORPORATION (US) | 2000-01-18 | — | — | US | disclosed |
| US-5976535-A | ADMINISTERING A FIRST CONJUGATE COMPRISING A TARGETING MOIETY AND STREPTAVIDIN; AND SUBSEQUENTLY ADMINISTERING A SECOND CONJUGATE COMPRISING A CYTOKINE AND BIOTIN, REDUCING THE ENDOGENOUS BIOTIN LEVEL | NEORX CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0733066-A4 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORP (US) | 1999-04-21 | — | — | EP | disclosed |
| EP-0733066-A1 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORPORATION (US) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015979-A1 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORPORATION (US) | 1995-06-15 | — | — | WO | disclosed |