Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | CXCR4 | P61073 | 5/20 | 0.49 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6328378 | 0.96 | CXCR4 (0.52) | HTTCXCR4HTR4DRD2DRD4 | |
| SCHEMBL7259058 | 0.90 | KCNH2 (0.56) | HTTHTR4DRD2DRD4DRD3 | |
| SCHEMBL7254037 | 0.90 | HTR4 (0.51) | HTTHTR4DRD2DRD4DRD3 | |
| SCHEMBL6328740 | 0.87 | HDAC3 (0.50) | HTTHTR4DRD2DRD4DRD3 | |
| SCHEMBL6329054 | 0.87 | TP53 (0.57) | HTTCXCR4HTR4DRD2DRD4 | |
| SCHEMBL6329791 | 0.87 | KCNH2 (0.61) | HTTHTR4DRD2DRD4DRD3 | |
| SCHEMBL6329006 | 0.87 | HTR4 (0.52) | HTTHTR4DRD2DRD4DRD3 | |
| SCHEMBL6329269 | 0.87 | DRD2 (0.58) | HTR4DRD2DRD4DRD3 | |
| SCHEMBL6336358 | 0.85 | HTR4 (0.56) | HTR4DRD2DRD4DRD3 | |
| SCHEMBL7257582 | 0.85 | HTR4 (0.61) | HTR4DRD2DRD4DRD3CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003057688-A2 | OXO OR OXY-PYRIDINE COMPOUNDS AS 5-HT4 RECEPTOR MODULATORS | PFIZER JAPAN INC. (JP) | 2003-07-17 | — | — | WO | disclosed |