Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.49 |
| ▸ | GHSR | Q92847 | 1/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.44 |
| ▸ | TUBB | P07437 | 2/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL826464 | 0.84 | ALDH1A1 (0.85) | ALDH1A1LMNAPTGES2TUBB1HTT | |
| SCHEMBL826463 | 0.84 | ALDH1A1 (0.85) | ALDH1A1LMNAPTGES2TUBB1HTT | |
| SCHEMBL1122229 | 0.83 | ALDH1A1 (0.74) | ALDH1A1LMNAPTGES2HTTKMT2A | |
| SCHEMBL1122677 | 0.79 | ALDH1A1 (0.68) | ALDH1A1LMNAPTGES2TUBB1HTT | |
| SCHEMBL1123111 | 0.78 | BACE1 (0.47) | ALDH1A1LMNAGHSRTUBB1MAPT | |
| SCHEMBL827806 | 0.78 | ALDH1A1 (0.74) | ALDH1A1LMNAPTGES2KMT2APKM | |
| SCHEMBL5622505 | 0.78 | CYP19A1 (0.64) | ALDH1A1LMNAHTTKMT2APKM | |
| SCHEMBL1122440 | 0.78 | ALDH1A1 (0.58) | ALDH1A1LMNAPTGES2TUBB1HTT | |
| SCHEMBL827807 | 0.78 | ALDH1A1 (0.74) | ALDH1A1LMNAPTGES2KMT2APKM | |
| SCHEMBL826539 | 0.77 | ALDH1A1 (1.00) | ALDH1A1LMNAPTGES2GHSRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6646009-B2 | Use against proliferative disorders including cancer, and as a radioprotective compound for normal cells from ionizing radiation | Temple University — Of Commonwealth System of Higher Education | 2003-11-11 | — | — | US | disclosed |
| US-20020165412-A1 | N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof | ONCONOVA THERAPEUTICS, INC. | 2002-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020165412-A1 | N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof | HCCS, NAT1, ARSA | ALDH1A1 678/4885LMNA 3112/4885PTGES2 2211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.