Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5097945 | 0.87 | MAPT (0.59) | MAPTALDH1A1SMN1; SMN2MAPK1LMNA | |
| SCHEMBL22471135 | 0.85 | MAPT (0.60) | MAPTALDH1A1SMN1; SMN2MAPK1LMNA | |
| SCHEMBL6377084 | 0.85 | LMNA (0.58) | MAPTALDH1A1SMN1; SMN2MAPK1LMNA | |
| SCHEMBL6370911 | 0.81 | MAPT (0.53) | MAPTALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL6370907 | 0.81 | MAPT (0.53) | MAPTALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL22471148 | 0.81 | MAPT (0.62) | MAPTALDH1A1SMN1; SMN2MAPK1LMNA | |
| SCHEMBL15834179 | 0.80 | MAPT (0.55) | MAPTALDH1A1SMN1; SMN2MAPK1LMNA | |
| SCHEMBL5552187 | 0.78 | MAPT (0.64) | MAPTALDH1A1SMN1; SMN2MAPK1LMNA | |
| SCHEMBL311195 | 0.77 | MAPT (0.79) | MAPTALDH1A1SMN1; SMN2MAPK1LMNA | |
| SCHEMBL7259542 | 0.77 | MEN1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003093250-A2 | POSITIVE ALLOSTERIC MODULATORS OF THE NICOTINIC ACETYLCHOLINE RECEPTOR | PHARMACIA & UPJOHN COMPANY (US) | 2003-11-13 | — | — | WO | disclosed |