Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.48 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.48 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6377084 | 0.87 | LMNA (0.58) | MAPTALDH1A1L3MBTL1CYP2C19LMNA | |
| SCHEMBL7259673 | 0.87 | MAPT (0.56) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL5098517 | 0.85 | ALDH1A1 (0.62) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL6370907 | 0.84 | MAPT (0.53) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL6370911 | 0.84 | MAPT (0.53) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL9515788 | 0.83 | MAPT (0.63) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL5224742 | 0.78 | ALDH1A1 (0.54) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL30180181 | 0.77 | MEN1 (0.50) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL25891601 | 0.77 | ALDH1A1 (0.68) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL6219907 | 0.77 | MAPT (0.64) | MAPTALDH1A1CYP1A2CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7427683-B2 | c-fms kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-09-23 | — | — | US | disclosed |
| EP-1812425-A2 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006047479-A2 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | WO | disclosed |
| US-20050131022-A1 | C-fms kinase inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131022-A1 | C-fms kinase inhibitors | FLT3, FES, FGR | MAPT 296/4885ALDH1A1 4568/4885L3MBTL1 1019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.