Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 2/20 | 0.34 |
| ▸ | RBPJ | Q06330 | 2/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480904 | 0.91 | CRHR1 (0.31) | TDP1CTSK | |
| SCHEMBL7487031 | 0.86 | CCKBR (0.33) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL6385267 | 0.85 | NOTCH1 (0.39) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7481197 | 0.83 | NOTCH1 (0.37) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7598317 | 0.83 | PSEN1 (0.40) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7482520 | 0.83 | PSEN1 (0.40) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7484257 | 0.83 | PSEN1 (0.40) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7486538 | 0.83 | PSEN1 (0.40) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7483243 | 0.83 | PSEN1 (0.34) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7596106 | 0.81 | CCKBR (0.34) | NOTCH1RBPJTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030166636-A1 | Hydroxyalkanoylaminolactams and related structures as inhibitors of A-beta protein production | OLSON RICHARD E (US) | 2003-09-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166636-A1 | Hydroxyalkanoylaminolactams and related structures as inhibitors of A-beta protein production | APP, APH1A, APH1B | NOTCH1 622/4885RBPJ 2748/4885PSEN1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.