Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TDO2 | P48775 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9213561 | 0.97 | DRD2 (0.59) | DRD2KDM4EALOX15HSD17B10ALDH1A1 | |
| Ethylene SCHEMBL6642130 | 0.80 | SLC6A4 (0.56) | DRD2HTR2CHTR1ASLC6A4HTR6 | |
| SCHEMBL12367429 | 0.78 | SLC6A4 (0.50) | DRD2KDM4EALOX15HSD17B10ALDH1A1 | |
| Ethylene SCHEMBL7481976 | 0.77 | DRD2 (0.57) | DRD2KDM4EALOX15HSD17B10ALDH1A1 | |
| SCHEMBL6634772 | 0.77 | SLC6A4 (0.59) | DRD2KDM4EHTR2CHTR1ASLC6A4 | |
| SCHEMBL3209524 | 0.75 | FLT3 (0.40) | DRD2KDM4EALOX15HSD17B10ALDH1A1 | |
| SCHEMBL2266189 | 0.74 | SLC6A4 (0.54) | DRD2KDM4EALOX15HSD17B10ALDH1A1 | |
| SCHEMBL28773698 | 0.74 | KDM4E (0.50) | DRD2KDM4EALOX15HSD17B10ALDH1A1 | |
| SCHEMBL6639190 | 0.73 | HTR6 (0.67) | HTR1ASLC6A4HTR6 | |
| SCHEMBL6296691 | 0.73 | DRD2 (0.60) | DRD2KDM4EALOX15HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6642228-B1 | Treating ocular tension, carcinoma, sarcoma, tumentia, circulatory disease, or hypertension | TORAY INDUSTRIES, INC. (JP) | 2003-11-04 | — | — | US | disclosed |
| EP-1106605-A1 | ALPHA1B-ADRENERGIC RECEPTOR ANTAGONISTS | TORAY INDUSTRIES, INC. (JP) | 2001-06-13 | — | — | EP | disclosed |
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | disclosed |
| US-5124332-A | Dopaminergic agents, hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1992-06-23 | — | — | US | disclosed |