Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.35 |
| ▸ | EGFR | P00533 | 5/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7260150 | 1.00 | RAB9A (0.39) | RAB9AELANEMAPTTP53KDR | |
| SCHEMBL7260147 | 0.80 | RAB9A (0.36) | RAB9AMAPTTP53KDRSMN1; SMN2 | |
| SCHEMBL7260154 | 0.80 | RAB9A (0.35) | RAB9AMAPTTP53KDRSMN1; SMN2 | |
| SCHEMBL6887783 | 0.79 | ELANE (0.42) | RAB9AELANEMAPTTP53NPC1 | |
| SCHEMBL7105524 | 0.79 | ELANE (0.42) | RAB9AELANEMAPTTP53KDR | |
| SCHEMBL7105519 | 0.79 | ELANE (0.42) | RAB9AELANEMAPTTP53KDR | |
| SCHEMBL7105190 | 0.78 | RAB9A (0.47) | RAB9AMAPTTP53KDRSMN1; SMN2 | |
| SCHEMBL7105195 | 0.78 | RAB9A (0.47) | RAB9AMAPTTP53KDRSMN1; SMN2 | |
| SCHEMBL7105523 | 0.77 | EGFR (0.45) | RAB9AKDREGFR | |
| SCHEMBL7099265 | 0.77 | ITGB1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518283-B1 | To modify integrin function in such a way as to beneficially modulate cell adhesion | CELLTECH R&D LIMITED (GB) | 2003-02-11 | — | — | US | disclosed |