Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | GSK3B | P49841 | 6/20 | 0.40 |
| ▸ | GSK3A | P49840 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1496202 | 0.84 | DYRK1A (0.47) | MAPK1GSK3BGSK3ADYRK1ACDK2 | |
| SCHEMBL7261192 | 0.79 | ALDH1A1 (0.42) | MAPK1GSK3BGSK3ASMN1; SMN2CDK2 | |
| SCHEMBL1593623 | 0.78 | GSK3B (0.59) | MAPK1GSK3BGSK3ASMN1; SMN2LMNA | |
| SCHEMBL1496216 | 0.76 | PDPK1 (0.43) | MAPK1GSK3BGSK3ACDK2MAP4K4 | |
| SCHEMBL7256652 | 0.75 | BRAF (0.56) | MAPK1GSK3BGSK3ADYRK1ACDK2 | |
| SCHEMBL19728696 | 0.74 | MAPK1 (0.46) | MAPK1GSK3BGSK3ASMN1; SMN2AAK1 | |
| SCHEMBL29253947 | 0.74 | GSK3A (0.48) | MAPK1GSK3BGSK3AAAK1DYRK1A | |
| SCHEMBL1496185 | 0.71 | GSK3B (0.36) | GSK3B | |
| SCHEMBL23107942 | 0.70 | HAO1 (0.40) | ALDH1A1LMNA | |
| SCHEMBL7255197 | 0.69 | MAPK1 (0.62) | MAPK1GSK3BGSK3AAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003068773-A1 | PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |