Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.46 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.46 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.46 |
| ▸ | AGXT | P21549 | 1/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1446773 | 0.77 | MAP4K4 (0.49) | MAP4K4MEN1KMT2AJAK3 | |
| SCHEMBL6919267 | 0.77 | IMPDH2 (0.48) | MAP4K4MEN1KMT2ACYP11B1CYP11B2 | |
| SCHEMBL17491540 | 0.76 | PIK3CA (0.42) | LMNAARIMPDH2CNR2JAK3 | |
| SCHEMBL2158739 | 0.76 | KMT2A (0.75) | MAP4K4MEN1KMT2ALMNACYP11B1 | |
| SCHEMBL6918908 | 0.76 | MAP4K4 (0.47) | MAP4K4MEN1KMT2ACYP11B1CYP11B2 | |
| SCHEMBL11210288 | 0.75 | LMNA (0.68) | KMOAGXTCYP1A1CYP1A2CYP1B1 | |
| SCHEMBL22209788 | 0.74 | MAP4K4 (0.48) | MAP4K4MEN1KMT2ALMNACYP11B1 | |
| SCHEMBL27329825 | 0.74 | LMNA (0.71) | MEN1KMT2AKMOPLOD2PLOD3 | |
| SCHEMBL14910832 | 0.73 | LRRK2 (0.48) | MEN1KMT2ARPS6KA3KMOPLOD2 | |
| SCHEMBL11992439 | 0.73 | LRRK2 (0.48) | RPS6KA3KMOPLOD2PLOD3PLOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101910158-A | Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders | ASTRAZENECA AB | 2010-12-08 | — | — | CN | disclosed |