Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.46 |
| ▸ | VEGFA | P15692 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | IL1RN | P18510 | 2/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.41 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7256476 | 0.95 | EGLN1 (0.47) | EGLN1VEGFAPARP1FABP4FABP5 | |
| SCHEMBL7256310 | 0.88 | PARP1 (0.55) | EGLN1VEGFAPARP1FABP4FABP5 | |
| SCHEMBL16088173 | 0.80 | ALDH1A1 (0.49) | EGLN1VEGFAMMP2MMP9MAPT | |
| SCHEMBL7256324 | 0.79 | TNF (0.46) | PARP1FABP4FABP5PTGS1PTGS2 | |
| SCHEMBL27636352 | 0.79 | ALDH1A1 (0.48) | EGLN1VEGFAPTGS1PTGS2MMP2 | |
| SCHEMBL31041845 | 0.79 | ALDH1A1 (0.48) | EGLN1VEGFAPTGS1PTGS2MMP2 | |
| SCHEMBL13962027 | 0.78 | EGLN1 (0.50) | EGLN1VEGFAPARP1MMP2MMP9 | |
| SCHEMBL9453852 | 0.78 | ALDH1A1 (0.54) | EGLN1VEGFAMMP2MMP9 | |
| SCHEMBL5179205 | 0.78 | EGLN1 (0.53) | EGLN1VEGFAMMP2MMP9IL1RN | |
| SCHEMBL14221996 | 0.77 | PARP1 (0.44) | PARP1FABP4FABP5KAT2AKAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003103668-A1 | PYRIDIN-2-ONE AND QUINOLIN-2-ONE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF AS ANTIBACTERIALS | KARO BIO AB (SE) | 2003-12-18 | — | — | WO | claimed |
| WO-2003103668-A1 | PYRIDIN-2-ONE AND QUINOLIN-2-ONE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF AS ANTIBACTERIALS | KARO BIO AB (SE) | 2003-12-18 | — | — | WO | disclosed |