Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | CDC25B | P30305 | 10/20 | 0.46 |
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | APAF1 | O14727 | 6/20 | 0.44 |
| ▸ | CASP3 | P42574 | 6/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 6/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 6/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.44 |
| ▸ | CASP6 | P55212 | 4/20 | 0.44 |
| ▸ | TNKS | O95271 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 3/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | UBE2I | P63279 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GALK1 | P51570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343701 | 0.79 | LOXL2 (0.60) | LOXL2KDM4EGAACDC25BTHRB | |
| SCHEMBL28566574 | 0.78 | LOXL2 (0.55) | LOXL2 | |
| SCHEMBL2599466 | 0.78 | LOXL2 (0.74) | LOXL2KDM4EGAACDC25BTHRB | |
| SCHEMBL1720643 | 0.78 | LOXL2 (0.68) | LOXL2KDM4EGAACDC25BTHRB | |
| SCHEMBL6646959 | 0.77 | LOXL2 (0.58) | LOXL2KDM4EGAACDC25BTHRB | |
| SCHEMBL2532412 | 0.77 | PARP1 (0.65) | LOXL2KDM4EGAAAPAF1CASP3 | |
| SCHEMBL6603861 | 0.77 | LOXL2 (0.62) | LOXL2KDM4EGAACDC25BTHRB | |
| SCHEMBL6647824 | 0.75 | LOXL2 (0.55) | LOXL2KDM4EGAACDC25BTHRB | |
| SCHEMBL7946899 | 0.75 | LOXL2 (0.55) | LOXL2KDM4EGAACDC25BTHRB | |
| SCHEMBL31386969 | 0.75 | PARP1 (0.42) | LOXL2KDM4ECDC25BTHRBTNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1284967-A1 | 3-SUBSTITUTED ISOQUINOLIN-1-YL DERIVATIVES | Celltech R&D Limited (GB) | 2003-02-26 | — | — | EP | disclosed |
| WO-2001092233-A1 | 3-SUBSTITUTED ISOQUINOLIN-1-YL DERIVATIVES | CELLTECH R & D LIMITED (GB) | 2001-12-06 | — | — | WO | disclosed |