Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.49 |
| ▸ | GRB2 | P62993 | 1/20 | 0.42 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902079 | 0.94 | PTPN1 (0.51) | PTPN1GRB2MDM4TP53MDM2 | |
| SCHEMBL23446219 | 0.86 | PTPN1 (0.47) | PTPN1MDM4TP53MDM2 | |
| SCHEMBL17182790 | 0.86 | MDM4 (0.40) | PTPN1MDM4TP53MDM2 | |
| SCHEMBL29755484 | 0.85 | PTPN1 (0.55) | PTPN1MDM4TP53MDM2 | |
| SCHEMBL27728772 | 0.84 | MDM4 (0.49) | MDM4TP53MDM2 | |
| SCHEMBL29978024 | 0.84 | PTPN1 (0.54) | PTPN1GRB2MDM4TP53MDM2 | |
| SCHEMBL14729329 | 0.84 | PTPN1 (0.47) | PTPN1MDM4TP53MDM2 | |
| SCHEMBL18145431 | 0.84 | PTPN1 (0.47) | PTPN1MDM4TP53MDM2 | |
| SCHEMBL23728660 | 0.84 | MDM2 (0.53) | PTPN1MDM4TP53MDM2 | |
| SCHEMBL20998310 | 0.84 | PTPN1 (0.49) | PTPN1MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728018-B1 | New enzymes and prodrugs for ADEPT | WELLCOME FOUND (GB) | 2003-08-06 | — | — | EP | disclosed |
| US-6140100-A | CONJUGATE POLYPEPTIDE WHICH IS TISSUE PREFERENTIAL; ANTICARCINOGENIC AGENTS | GLAXO WELLCOME INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0728018-A1 | THERAPY | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013095-A2 | THERAPY | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |