Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7268046 | 0.85 | CYSLTR1 (0.44) | KDM4EALDH1A1HPGDCYP1A2CYP2C9 | |
| SCHEMBL7268766 | 0.78 | PTGDR2 (0.45) | PTGDR2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4710219 | 0.75 | ALOX5 (0.49) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL4710220 | 0.75 | ALOX5 (0.49) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL4715316 | 0.73 | MEN1 (0.51) | NPC1RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL4715315 | 0.73 | MEN1 (0.51) | NPC1RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL10813695 | 0.70 | KDM4E (0.48) | PTGDR2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL10813700 | 0.70 | KDM4E (0.48) | PTGDR2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7266628 | 0.70 | RAB9A (0.54) | NPC1RAB9AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL27481842 | 0.69 | RAB9A (0.44) | NPC1RAB9AKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656957-B1 | Marked and selective modulating, especially antagonistic, action at human metabotropic glutamate receptors (mGluRs); treatment of disorders such as epilepsy, cerebral ischemias, especially acute ischemias, spasticity etc. | NOVARTIS AG (CH) | 2003-12-02 | — | — | US | disclosed |