Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31381768 | 0.77 | PDE10A (0.34) | TLR8 | |
| SCHEMBL246415 | 0.77 | CCR1 (0.39) | TLR8KCNH2 | |
| SCHEMBL29865866 | 0.77 | CCR1 (0.39) | TLR8KCNH2 | |
| SCHEMBL3850029 | 0.75 | HTR3A (0.51) | — | |
| SCHEMBL3748371 | 0.75 | KCNH2 (0.37) | TLR8KCNH2 | |
| SCHEMBL221129 | 0.74 | GAA (0.41) | — | |
| SCHEMBL2968640 | 0.73 | KCNH2 (0.53) | TLR8KCNH2APLNR | |
| SCHEMBL31098172 | 0.72 | ALDH1A1 (0.40) | — | |
| SCHEMBL2650003 | 0.72 | KCNH2 (0.35) | KCNH2 | |
| SCHEMBL12615482 | 0.72 | KCNH2 (0.35) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525200-B1 | Fused pyridine and cyclohexane rings and having optionally other substituents; complexing and quantitating such as urea or guanidine | ROCHE DIAGNOSTICS CORPORATION | 2003-02-25 | — | — | US | disclosed |
| WO-2002014465-A2 | MULTICYCLIC AROMATIC COMPOUNDS AND USES THEREOF | ROCHE DIAGNOSTICS CORPORATION (US) | 2002-02-21 | — | — | WO | disclosed |