Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 13/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 6/20 | 0.34 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.31 |
| ▸ | ABAT | P80404 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6449762 | 0.83 | PTGDR2 (0.37) | PTGDR2PTGDRPTGER2 | |
| SCHEMBL7257541 | 0.83 | KDM4E (0.44) | ALDH1A1PTGDR2PTGDRHPGDTDP1 | |
| SCHEMBL7257530 | 0.83 | KDM4E (0.44) | ALDH1A1PTGDR2PTGDRHPGDTDP1 | |
| SCHEMBL26132269 | 0.82 | ALDH1A1 (0.36) | ALDH1A1TSHRAOX1DRD2ALDH1A3 | |
| SCHEMBL7262052 | 0.81 | NR1H4 (0.43) | ALDH1A1PTGDR2PTGDRHPGD | |
| SCHEMBL7262044 | 0.81 | NR1H4 (0.43) | ALDH1A1PTGDR2PTGDRHPGD | |
| SCHEMBL3925300 | 0.80 | PTGDR2 (0.39) | ALDH1A1TSHRPTGDR2PTGDRAOX1 | |
| SCHEMBL6449169 | 0.80 | PTGDR2 (0.51) | ALDH1A1PTGDR2PTGDRPTGER2HPGD | |
| SCHEMBL6407399 | 0.79 | ALDH1A1 (0.56) | ALDH1A1TSHRPTGDR2PTGDRAOX1 | |
| SCHEMBL30360260 | 0.78 | ALDH1A1 (0.50) | ALDH1A1TSHRAOX1DRD2ALDH1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728018-B1 | New enzymes and prodrugs for ADEPT | WELLCOME FOUND (GB) | 2003-08-06 | — | — | EP | disclosed |
| US-6319702-B1 | NUCLEOTIDE SEQUENCS CODING AN ENZYMATIC POLYPEPTIDE AND CELL TARGETING COMPOUND; FOR USE IN TREATMENT OF CANCER | GLAXO WELLCOME, INC. | 2001-11-20 | — | — | US | disclosed |
| US-6140100-A | CONJUGATE POLYPEPTIDE WHICH IS TISSUE PREFERENTIAL; ANTICARCINOGENIC AGENTS | GLAXO WELLCOME INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0728018-A1 | THERAPY | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013095-A2 | THERAPY | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |