Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | TOP2A | P11388 | 1/20 | 0.30 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7936668 | 0.81 | TAAR1 (0.38) | TAAR1HTR1AAOC3KDM4EALDH1A1 | |
| SCHEMBL7939457 | 0.78 | TAAR1 (0.39) | TAAR1HTR1AADORA3ADORA2AADORA2B | |
| SCHEMBL7715276 | 0.71 | — | — | |
| SCHEMBL6432861 | 0.70 | FDPS (0.45) | TAAR1HTR1AKDM4EALDH1A1 | |
| Bromide SCHEMBL6435571 | 0.69 | FDPS (0.44) | TAAR1HTR1AKDM4EALDH1A1 | |
| SCHEMBL6432281 | 0.65 | DAO (0.42) | — | |
| SCHEMBL29912527 | 0.64 | L3MBTL1 (0.38) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL22854912 | 0.64 | L3MBTL1 (0.38) | KDM4EALDH1A1HPGDHSD17B10 | |
| Bromide SCHEMBL6409244 | 0.64 | DAO (0.42) | — | |
| SCHEMBL10518960 | 0.63 | TAAR1 (0.56) | TAAR1HTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1332134-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2003-08-06 | — | — | EP | disclosed |
| WO-2002060868-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2002-08-08 | — | — | WO | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |