Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 7/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | GLA | P06280 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588631 | 0.91 | TYMS (0.50) | TYMSHSD17B10ALDH1A1HPGDCYP1A2 | |
| Bicarbonate SCHEMBL3836308 | 0.87 | CYP1A2 (0.55) | HSD17B10ALDH1A1HPGDCYP1A2THRB | |
| Bicarbonate SCHEMBL636595 | 0.87 | CYP1A2 (0.55) | HSD17B10ALDH1A1HPGDCYP1A2THRB | |
| Bicarbonate SCHEMBL2585744 | 0.87 | CYP1A2 (0.55) | HSD17B10ALDH1A1HPGDCYP1A2THRB | |
| Bicarbonate SCHEMBL11125272 | 0.85 | ALDH1A1 (0.40) | TYMSHSD17B10ALDH1A1HPGDCYP1A2 | |
| Bicarbonate SCHEMBL7451205 | 0.83 | TYMS (0.41) | TYMSHSD17B10ALDH1A1HPGDCYP1A2 | |
| Bicarbonate SCHEMBL1128136 | 0.82 | CYP1A2 (0.35) | TYMSHSD17B10ALDH1A1HPGDCYP1A2 | |
| Bicarbonate SCHEMBL10975774 | 0.82 | KMT2A (0.35) | TYMSHSD17B10ALDH1A1HPGDCYP1A2 | |
| Bicarbonate SCHEMBL5017274 | 0.82 | AHR (0.35) | TYMSHSD17B10ALDH1A1HPGDCYP1A2 | |
| Bicarbonate SCHEMBL11122358 | 0.81 | KDM4E (0.35) | TYMSHSD17B10ALDH1A1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149757-B1 | PRINTED INTERLAYER FILMS FOR LAMINATED GLAZING WITH IMPROVED NIR TRANSPARENCY | KURARAY EUROPE GMBH (DE) | 2024-04-17 | — | — | EP | claimed |
| EP-3816238-B9 | POLYPARAPERYLENE DERIVATIVES AND METHODS FOR MAKING SAME | TEXTILCHEMIE DR PETRY GMBH (DE) | 2023-06-21 | — | — | EP | claimed |
| EP-3816238-B1 | POLYPARAPERYLENE DERIVATIVES AND METHODS FOR MAKING SAME | TEXTILCHEMIE DR PETRY GMBH (DE) | 2023-04-12 | — | — | EP | claimed |
| EP-2181466-B1 | GROWTH OF ORDERED CRYSTALLINE ORGANIC FILMS | UNIV MICHIGAN REGENTS (US) | 2021-03-10 | — | — | EP | claimed |
| EP-3230295-B1 | AMINO PHOSPHAZENE BASES AS N-DOPANTS IN ORGANIC ELECTRONICS | SIEMENS AG (DE) | 2019-07-31 | — | — | EP | claimed |
| EP-3233873-B1 | PROAZAPHOSPHATRANES AS N-DOPANTS IN ORGANIC ELECTRONICS | SIEMENS AG (DE) | 2019-06-26 | — | — | EP | claimed |
| EP-2586585-B1 | THERMOPLASTIC COMPOSITE MATERIAL REINFORCED WITH SYNTHETIC FIBRES AND MANUFACTURING METHOD | ARKEMA FRANCE (FR) | 2018-01-24 | — | — | EP | claimed |
| EP-3233873-A1 | PROAZAPHOSPHATRANES AS N-DOPANTS IN ORGANIC ELECTRONICS | Siemens Aktiengesellschaft (DE) | 2017-10-25 | — | — | EP | claimed |
| EP-3230295-A1 | AMINO PHOSPHAZENE BASES AS N-DOPANTS IN ORGANIC ELECTRONICS | Siemens Aktiengesellschaft (DE) | 2017-10-18 | — | — | EP | claimed |
| WO-2016116205-A1 | PROAZAPHOSPHATRANES AS N-DOPANTS IN ORGANIC ELECTRONICS | SIEMENS AKTIENGESELLSCHAFT (DE) | 2016-07-28 | — | — | WO | claimed |
| EP-0176900-B1 | PROCESS FOR THE MANUFACTURE OF MIXED CRYSTALS OF PIGMENTS ON THE BASIS OF DIIMIDES OF PERYLENE TETRACARBOXYLIC ACID, AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-04-24 | — | — | EP | claimed |
| EP-0176902-B1 | MIXED CRYSTALS OF PIGMENTS ON THE BASIS OF DIIMIDES OF PERYLENE TETRACARBOXYLIC ACID, THEIR MANUFACTURING PROCESS AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-04-10 | — | — | EP | claimed |
| EP-0176899-B1 | MIXED CRYSTALS OF PIGMENTS ON THE BASIS OF DIIMIDES OF PERYLENE TETRACARBOXYLIC ACID, THEIR MANUFACTURING PROCESS AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-04-03 | — | — | EP | claimed |
| EP-0122879-B1 | PROCESS FOR THE PREPARATION OF PERYLENE | CIBA-GEIGY AG (CH) | 1986-08-27 | — | — | EP | claimed |
| EP-0176900-A2 | Process for the manufacture of mixed crystals of pigments on the basis of diimides of perylene tetracarboxylic acid, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-04-09 | — | — | EP | claimed |
| EP-0176902-A2 | Mixed crystals of pigments on the basis of diimides of perylene tetracarboxylic acid, their manufacturing process and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-04-09 | — | — | EP | claimed |
| EP-0176899-A2 | Mixed crystals of pigments on the basis of diimides of perylene tetracarboxylic acid, their manufacturing process and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-04-09 | — | — | EP | claimed |
| EP-0122879-A1 | Process for the preparation of perylene | CIBA-GEIGY AG (CH) | 1984-10-24 | — | — | EP | claimed |
| EP-0023191-B1 | MODIFICATION OF PERYLENE-TETRACARBOXYLIC ACID BIS (3,5-DIMETHYLPHENYL) IMIDE, ITS PREPARATION AND USE IN PIGMENTATION | CIBA-GEIGY AG (CH) | 1983-02-09 | — | — | EP | claimed |
| EP-0023191-A1 | Modification of perylene-tetracarboxylic acid bis (3,5-dimethylphenyl) imide, its preparation and use in pigmentation | CIBA-GEIGY AG (CH) | 1981-01-28 | — | — | EP | claimed |