Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 8/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7264144 | 0.89 | GABRG2 (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL4410188 | 0.88 | GABRG2 (0.58) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7263577 | 0.88 | GABRG2 (0.45) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7272498 | 0.87 | GABRG2 (0.45) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7263615 | 0.86 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7264072 | 0.86 | GABRA1 (0.44) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7271283 | 0.86 | GABRG2 (0.44) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7264146 | 0.85 | GABRG2 (0.43) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7265329 | 0.84 | GABRG2 (0.43) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7263624 | 0.83 | GABRG2 (0.50) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0059391-A1 | Imidazodiazepines, process for their preparation and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-08 | — | — | EP | claimed |
| EP-0059391-A1 | Imidazodiazepines, process for their preparation and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-08 | — | — | EP | disclosed |