Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL7263661 | 1.00 | ACE (0.47) | ACELMNASMN1; SMN2ERAP2ERAP1 | |
| Arginine SCHEMBL7263656 | 0.91 | ACE (0.41) | ACELMNA | |
| Arginine SCHEMBL7264226 | 0.90 | OPRM1 (0.41) | ACEERAP2ERAP1LNPEP | |
| Arginine SCHEMBL7264437 | 0.90 | OPRM1 (0.41) | ACEERAP2ERAP1LNPEP | |
| Arginine SCHEMBL7264275 | 0.89 | ACE (0.41) | ACEERAP2ERAP1LNPEP | |
| Arginine SCHEMBL7264243 | 0.89 | ACE (0.41) | ACELMNA | |
| Lysine SCHEMBL7265715 | 0.88 | ACE (0.53) | ACELMNA | |
| Arginine SCHEMBL7265626 | 0.88 | ACE (0.38) | ACELMNA | |
| Arginine SCHEMBL7270511 | 0.88 | ACE (0.38) | ACELMNA | |
| Arginine SCHEMBL7271460 | 0.88 | EPHA2 (0.43) | ACEERAP2ERAP1LNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4590178-A | DIURETICS | AJINOMOTO COMPANY, INCORPORATED (JP) | 1986-05-20 | — | — | US | disclosed |
| US-4536395-A | DIPEPTIDES | AJINOMOTO CO., INC. (JP) | 1985-08-20 | — | — | US | disclosed |
| US-4472381-A | Amino acid derivatives, methods of preparing said derivatives and antihypertensive drugs containing them | AJINOMOTO COMPANY INCORPORATED (JP) | 1984-09-18 | — | — | US | disclosed |
| EP-0085488-A2 | Amino acid derivatives and antihypertensive drugs containing them | AJINOMOTO CO., INC. (JP) | 1983-08-10 | — | — | EP | disclosed |