Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 5/20 | 0.41 |
| ▸ | PPID | Q08752 | 3/20 | 0.37 |
| ▸ | PPIG | Q13427 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263927 | 0.89 | ACE (0.48) | ACE | |
| Arginine SCHEMBL7263661 | 0.89 | ACE (0.47) | ACELMNA | |
| Arginine SCHEMBL7264429 | 0.89 | ACE (0.47) | ACELMNA | |
| SCHEMBL7265471 | 0.87 | ACE (0.48) | ACELMNA | |
| Arginine SCHEMBL7263656 | 0.85 | ACE (0.41) | ACELMNA | |
| Arginine SCHEMBL7270466 | 0.83 | ACE (0.42) | ACE | |
| Hydrochloric Acid SCHEMBL11115544 | 0.80 | ACE (0.43) | ACEPPIDPPIGLMNA | |
| Arginine SCHEMBL7264274 | 0.80 | ACE (0.43) | ACE | |
| Arginine SCHEMBL7264249 | 0.79 | BDKRB2 (0.38) | ACEBDKRB2 | |
| Arginine SCHEMBL10654400 | 0.79 | ACE (0.46) | ACELMNABDKRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4590178-A | DIURETICS | AJINOMOTO COMPANY, INCORPORATED (JP) | 1986-05-20 | — | — | US | disclosed |
| US-4536395-A | DIPEPTIDES | AJINOMOTO CO., INC. (JP) | 1985-08-20 | — | — | US | disclosed |
| US-4472381-A | Amino acid derivatives, methods of preparing said derivatives and antihypertensive drugs containing them | AJINOMOTO COMPANY INCORPORATED (JP) | 1984-09-18 | — | — | US | disclosed |
| EP-0085488-A2 | Amino acid derivatives and antihypertensive drugs containing them | AJINOMOTO CO., INC. (JP) | 1983-08-10 | — | — | EP | disclosed |