Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9434107 | 1.00 | ATM (0.39) | ATMNPSR1MAPTRAB9ATSHR | |
| SCHEMBL5755287 | 0.88 | SMN1; SMN2 (0.38) | ATMNPSR1MAPTRAB9ATSHR | |
| SCHEMBL26078304 | 0.88 | SMN1; SMN2 (0.38) | ATMNPSR1MAPTRAB9ATSHR | |
| SCHEMBL7657312 | 0.88 | SMN1; SMN2 (0.38) | ATMNPSR1MAPTRAB9ATSHR | |
| SCHEMBL759827 | 0.88 | TSHR (0.46) | ATMNPSR1MAPTRAB9ATSHR | |
| SCHEMBL27956667 | 0.88 | TSHR (0.46) | ATMNPSR1MAPTRAB9ATSHR | |
| SCHEMBL11006987 | 0.86 | TSHR (0.50) | ATMNPSR1MAPTRAB9ATSHR | |
| SCHEMBL11003632 | 0.86 | TSHR (0.50) | ATMNPSR1MAPTRAB9ATSHR | |
| SCHEMBL11006969 | 0.86 | TSHR (0.50) | ATMNPSR1MAPTRAB9ATSHR | |
| SCHEMBL11003628 | 0.86 | TSHR (0.50) | ATMNPSR1MAPTRAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012123966-A1 | PROCESS FOR THE PREPARATION OF 4 -SUBSTITUTED -1, 4-DIHYDROPYRIDINES | ARCH PHARMALABS LIMITED (IN) | 2012-09-20 | — | — | WO | disclosed |
| EP-0371492-B1 | Process for the preparation of 1,4-dihydropyridine derivatives | NISSHIN FLOUR MILLING CO (JP) | 1995-06-21 | — | — | EP | disclosed |
| US-5276150-A | Vasodilators, anticoagulants, calcium channel blockers | FUJIREBIO INC. (JP) | 1994-01-04 | — | — | US | disclosed |
| EP-0184841-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |
| EP-0400660-A1 | 1,4-dihydropyridine derivatives | FUJIREBIO INC. (JP) | 1990-12-05 | — | — | EP | disclosed |
| EP-0371492-A2 | Process for the preparation of 1,4-dihydropyridine derivatives | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1990-06-06 | — | — | EP | disclosed |
| US-4757071-A | 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0184841-A2 | 1,4-Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions containing same | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1986-06-18 | — | — | EP | disclosed |
| US-4558058-A | HYPOTENSIVE AGENTS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1985-12-10 | — | — | US | disclosed |
| EP-0116708-A1 | Substituted 1,4-dihydropyridines, method for their preparation and their use as pharmaceuticals | CASSELLA Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |