Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.51 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490816 | 0.82 | HIF1A (0.62) | HIF1AEPAS1GPR84CTSVCTSL | |
| SCHEMBL29195192 | 0.82 | AOC3 (0.37) | HIF1AEPAS1GPR84SIGMAR1AOC3 | |
| SCHEMBL891349 | 0.80 | HIF1A (0.66) | HIF1AEPAS1GPR84CTSVCTSL | |
| SCHEMBL17156491 | 0.80 | HIF1A (0.66) | HIF1AEPAS1GPR84CTSVCTSL | |
| SCHEMBL891143 | 0.80 | HIF1A (0.66) | HIF1AEPAS1GPR84CTSVCTSL | |
| SCHEMBL17156498 | 0.80 | HIF1A (0.60) | HIF1AEPAS1GPR84CTSVCTSL | |
| SCHEMBL890821 | 0.80 | HIF1A (0.66) | HIF1AEPAS1GPR84CTSVCTSL | |
| SCHEMBL890971 | 0.80 | CALM1 (0.58) | AOC3CAPN1 | |
| SCHEMBL891270 | 0.76 | HIF1A (0.53) | HIF1AEPAS1GPR84HTTMAPT | |
| SCHEMBL5503791 | 0.75 | CYP1A2 (0.56) | HIF1AEPAS1GPR84CTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003068738-A1 | PYRROLE DERIVATIVES AS LIGANDS OF MELANOCORTIN RECEPTORS | NEUROCRINE BIOSCIENCES, INC. (US) | 2003-08-21 | — | — | WO | disclosed |