Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | CTSV | O60911 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28313365 | 0.89 | GPR84 (0.53) | CYP1A2CYP2C9HSD17B10GPR84HIF1A | |
| SCHEMBL22734764 | 0.79 | CYP1A2 (0.55) | CYP1A2CYP2C9HSD17B10CTSVCTSL | |
| SCHEMBL490816 | 0.78 | HIF1A (0.62) | GPR84HIF1AEPAS1CTSVCTSL | |
| SCHEMBL17156491 | 0.76 | HIF1A (0.66) | HSD17B10GPR84HIF1AEPAS1CTSV | |
| SCHEMBL891349 | 0.76 | HIF1A (0.66) | HSD17B10GPR84HIF1AEPAS1CTSV | |
| SCHEMBL890821 | 0.76 | HIF1A (0.66) | HSD17B10GPR84HIF1AEPAS1CTSV | |
| SCHEMBL891143 | 0.76 | HIF1A (0.66) | HSD17B10GPR84HIF1AEPAS1CTSV | |
| SCHEMBL17156498 | 0.76 | HIF1A (0.60) | GPR84HIF1AEPAS1CTSVCTSL | |
| SCHEMBL7106433 | 0.76 | CYP1A2 (0.61) | CYP1A2CYP2C9HSD17B10MAPTKMT2A | |
| SCHEMBL7264646 | 0.75 | HIF1A (0.51) | GPR84HIF1AEPAS1HSD11B1CTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848692-A1 | AZOLYLACYLGUANIDINES AS ß-SECRETASE INHIBITORS | Wyeth (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006088711-A1 | AZOLYLACYLGUANIDINES AS β-SECRETASE INHIBITORS | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |