Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 12/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.34 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.34 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263749 | 0.90 | CACNA1B (0.38) | CACNA1BKMT2AMAPTACHETP53 | |
| SCHEMBL10995581 | 0.89 | CACNA1B (0.51) | CACNA1BMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7270530 | 0.87 | MEN1 (0.53) | CACNA1BMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7271866 | 0.85 | CYP2C9 (0.46) | MEN1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7265650 | 0.82 | ABCC1 (0.32) | CYP3A4CYP2C9CYP2C19TSHRCACNA1F | |
| SCHEMBL11002184 | 0.82 | CACNA1B (0.45) | CACNA1BMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7263910 | 0.81 | POLB (0.41) | CACNA1BMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7273183 | 0.80 | HSD17B10 (0.41) | KMT2AMAPTTSHR | |
| SCHEMBL7270521 | 0.80 | KMT2A (0.35) | MEN1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7271815 | 0.79 | MAPK1 (0.36) | MEN1CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116708-A1 | Substituted 1,4-dihydropyridines, method for their preparation and their use as pharmaceuticals | CASSELLA Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |