Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10995776 | 0.89 | HSD17B10 (0.52) | HSD17B10ALDH1A1CASP1HPGDCASP7 | |
| SCHEMBL7271866 | 0.86 | CYP2C9 (0.46) | HSD17B10ALDH1A1HPGDMAPTP2RX3 | |
| SCHEMBL7273136 | 0.85 | ALDH1A1 (0.41) | HSD17B10ALDH1A1CASP1HPGDCASP7 | |
| SCHEMBL7273125 | 0.82 | LMNA (0.47) | HSD17B10ALDH1A1HPGDMAPTP2RX3 | |
| SCHEMBL7265694 | 0.80 | CACNA1B (0.41) | MAPTTSHRKMT2A | |
| SCHEMBL7270530 | 0.78 | MEN1 (0.53) | MAPTTSHRKMT2A | |
| SCHEMBL7263995 | 0.77 | CYP2C9 (0.40) | HSD17B10ALDH1A1CASP1HPGDCASP7 | |
| SCHEMBL7265677 | 0.77 | CYP2C9 (0.46) | HSD17B10ALDH1A1HPGDMAPTTSHR | |
| SCHEMBL7271485 | 0.77 | CYP2C9 (0.43) | HSD17B10ALDH1A1HPGDMAPTTSHR | |
| SCHEMBL7270471 | 0.76 | CYP2C9 (0.41) | HSD17B10ALDH1A1HPGDMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116708-A1 | Substituted 1,4-dihydropyridines, method for their preparation and their use as pharmaceuticals | CASSELLA Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |