Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.61 |
| ▸ | CTSL | P07711 | 1/20 | 0.58 |
| ▸ | FKBP1A | P62942 | 8/20 | 0.57 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.57 |
| ▸ | CMA1 | P23946 | 5/20 | 0.54 |
| ▸ | ACE | P12821 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28545846 | 1.00 | PREP (0.61) | PREPCTSLFKBP1AKLK5CMA1 | |
| SCHEMBL10882017 | 1.00 | PREP (0.61) | PREPCTSLFKBP1AKLK5CMA1 | |
| SCHEMBL9699149 | 1.00 | PREP (0.61) | PREPCTSLFKBP1AKLK5CMA1 | |
| SCHEMBL7265619 | 0.96 | PREP (0.57) | PREPCTSLFKBP1AKLK5CMA1 | |
| SCHEMBL11760193 | 0.96 | PREP (0.57) | PREPCTSLFKBP1AKLK5CMA1 | |
| SCHEMBL8056455 | 0.96 | PREP (0.57) | PREPCTSLFKBP1AKLK5CMA1 | |
| SCHEMBL10416187 | 0.93 | PREP (0.65) | PREPCTSLFKBP1AKLK5CMA1 | |
| SCHEMBL3469545 | 0.93 | PREP (0.65) | PREPCTSLFKBP1AKLK5CMA1 | |
| SCHEMBL8366717 | 0.91 | CMA1 (0.65) | CTSLFKBP1AKLK5CMA1 | |
| SCHEMBL7305436 | 0.91 | CMA1 (0.65) | CTSLFKBP1AKLK5CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110105428-B | Leu-Arg-Ala-Pro-Leu-Tyr-Val heptapeptide, synthesis, activity and application thereof | 首都医科大学 | 2022-08-05 | — | — | CN | claimed |
| JP-60142999-A | — | — | None | — | — | JP | disclosed |
| CN-110105428-B | Leu-Arg-Ala-Pro-Leu-Tyr-Val heptapeptide, synthesis, activity and application thereof | 首都医科大学 | 2022-08-05 | — | — | CN | disclosed |
| CN-106866733-B | Levo meptazinol prodrug and preparation method and application thereof | 凯瑞康宁生物工程（武汉）有限公司 | 2020-11-20 | — | — | CN | disclosed |
| US-6130315-A | SUBSTRATES IN WHICH THE SCISSILE AMIDE BOND HAS BEEN REPLACED BY AN ACTIVATED ELECTROPHILIC KETONE MOIETY; ANTIINFLAMMATORY AGENTS; ANTIPROLIFERATIVE/ANTICARCINOGENIC/ANTIARTHRITIC AGENTS; TREATMENT OF AUTOIMMUNE DISEASES | MERRELL PHARMACEUTICALS INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5849866-A | Peptidase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1998-12-15 | — | — | US | disclosed |
| US-5496927-A | INHIBITORS OF HUMAN LEUKOCYTE ELASTASE, CATHEPSIN G, CHYMOTRYPSIN | MERRELL PHARMACEUTICALS INC. (US) | 1996-03-05 | — | — | US | disclosed |
| EP-0195212-B1 | Novel peptidase inhibitors | MERRELL DOW PHARMA (US) | 1993-11-24 | — | — | EP | disclosed |
| WO-1992004370-A1 | MODIFIED DI- AND TRIPEPTIDYL IMMUNOSUPPRESSIVE COMPOUNDS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1992-03-19 | — | — | WO | disclosed |
| EP-0195212-A2 | Novel peptidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-09-24 | — | — | EP | disclosed |
| US-4590178-A | DIURETICS | AJINOMOTO COMPANY, INCORPORATED (JP) | 1986-05-20 | — | — | US | disclosed |
| US-4536395-A | DIPEPTIDES | AJINOMOTO CO., INC. (JP) | 1985-08-20 | — | — | US | disclosed |
| US-4533656-A | PYRROLE OR PYRIDINE CARBONYLSULFONAMIDES FOR TREATMENT OF HYPERTENSION OR CONJESTIVE HEART FAILURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-08-06 | — | — | US | disclosed |
| JP-S60142999-A | ALANYLPROLINE DERIVATIVE AND ITS USE | AJINOMOTO CO INC | 1985-07-29 | — | — | JP | disclosed |
| US-4472381-A | Amino acid derivatives, methods of preparing said derivatives and antihypertensive drugs containing them | AJINOMOTO COMPANY INCORPORATED (JP) | 1984-09-18 | — | — | US | disclosed |
| EP-0099709-A2 | Amide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-02-01 | — | — | EP | disclosed |
| EP-0085488-A2 | Amino acid derivatives and antihypertensive drugs containing them | AJINOMOTO CO., INC. (JP) | 1983-08-10 | — | — | EP | disclosed |