Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265941 | 1.00 | TSHR (0.50) | TSHRATMNPSR1ACHEMAPT | |
| SCHEMBL3295702 | 0.89 | TSHR (0.39) | TSHRATMNPSR1MAPTRAB9A | |
| Ethylene Glycol SCHEMBL11055892 | 0.88 | TSHR (0.42) | TSHRATMNPSR1ACHEMAPT | |
| SCHEMBL31531957 | 0.86 | TSHR (0.41) | TSHRATMNPSR1ACHEMAPT | |
| SCHEMBL29182959 | 0.86 | TSHR (0.41) | TSHRATMNPSR1ACHEMAPT | |
| SCHEMBL759827 | 0.84 | TSHR (0.46) | TSHRATMNPSR1MAPTRAB9A | |
| SCHEMBL27956667 | 0.84 | TSHR (0.46) | TSHRATMNPSR1MAPTRAB9A | |
| SCHEMBL10923787 | 0.84 | TSHR (0.44) | TSHRATMNPSR1ACHEMAPT | |
| SCHEMBL9689622 | 0.84 | TSHR (0.44) | TSHRATMNPSR1ACHEMAPT | |
| SCHEMBL10919646 | 0.84 | TSHR (0.44) | TSHRATMNPSR1ACHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1067076-C | Substituted thiacycloalkeno [3,2-b] pyridines, methods of preparation, compositions and method of use | ORTHO PHARMA CORP (US) | 2001-06-13 | — | — | CN | disclosed |
| EP-0462696-B1 | Novel pyrido [2,3-f][1,4] thiazepines and pyrido [3,2-b][1,5] benzothiazepines | ORTHO PHARMA CORP (US) | 1995-08-09 | — | — | EP | disclosed |
| CN-1028759-C | Process for preparing substituted thiacycloalkeno (3, 2-b) pyridines | ORTHO PHARMA CORP (US) | 1995-06-07 | — | — | CN | disclosed |
| CN-1102185-A | Substituted thiacycloalkeno [3,2-b] pyridines, methods of preparation, compositions and method of use | ORTHO PHARMA CORP (US) | 1995-05-03 | — | — | CN | disclosed |
| EP-0241281-B1 | Substituted thiacycloalkeno [3,2-b] pyridines, methods of preparation, compositions and method of use | ORTHO PHARMA CORP (US) | 1994-07-27 | — | — | EP | disclosed |
| EP-0462696-A1 | Novel pyrido [2,3-f][1,4] thiazepines and pyrido [3,2-b][1,5] benzothiazepines | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-12-27 | — | — | EP | disclosed |
| US-5075440-A | Hypotensive, bronchodilator agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-12-24 | — | — | US | disclosed |
| US-4879384-A | CYCLIC THIAALKANONE DIOXIDE AND UNSATURATED AMINE ESTER | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-11-07 | — | — | US | disclosed |
| US-4845225-A | CARDIOVASCULAR, ANTIASTHMATIC AND ANTIBRONCHOCONSTRICTOR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-07-04 | — | — | US | disclosed |
| US-4777167-A | CALCIUM CHANNEL ANTAGONIST, ANTICOAGULANTS, ANTIASTHMATIC, BRONCHODILATOR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-10-11 | — | — | US | disclosed |
| US-4705785-A | Substituted thiacycloalkeno (3,2-b) pyridines and pharmaceutical compositions and method of use | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-11-10 | — | — | US | disclosed |
| CN-87102761-A | Substituted thiocycloalkeno (3, 2-b) pyridines, compositions, and methods of use | — | 1987-11-04 | — | — | CN | disclosed |
| EP-0241281-A2 | Substituted thiacycloalkeno [3,2-b] pyridines, methods of preparation, compositions and method of use | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-10-14 | — | — | EP | disclosed |