Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 7/20 | 0.57 |
| ▸ | CACNA1D | Q01668 | 7/20 | 0.57 |
| ▸ | CACNA1S | Q13698 | 7/20 | 0.57 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.57 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.56 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.54 |
| ▸ | CCKBR | P32239 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.54 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3940339 | 0.88 | CACNA1F (0.71) | MAPTCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL3032197 | 0.88 | CACNA1F (0.71) | MAPTCACNA1FCACNA1DCACNA1SCACNA1C | |
| Hydrochloric Acid SCHEMBL9374052 | 0.87 | CACNA1F (0.70) | MAPTCACNA1FCACNA1DCACNA1SCACNA1C | |
| Hydrochloric Acid SCHEMBL9805019 | 0.87 | CACNA1F (0.70) | MAPTCACNA1FCACNA1DCACNA1SCACNA1C | |
| Hydrochloric Acid SCHEMBL9805027 | 0.87 | CACNA1F (0.70) | MAPTCACNA1FCACNA1DCACNA1SCACNA1C | |
| Hydrochloric Acid SCHEMBL9374064 | 0.87 | CACNA1F (0.70) | MAPTCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7305006 | 0.86 | ADORA3 (0.67) | MAPTALDH1A1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7305002 | 0.86 | ADORA3 (0.67) | MAPTALDH1A1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7590982 | 0.86 | CACNA1F (0.80) | MAPTCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7272316 | 0.86 | CACNA1F (0.62) | MAPTALDH1A1CACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988717-A | Optically active 1,4-dihydropyridine esters useful for treating circulatory illnesses | BAYER AKTIENGESELLSCHAFT (DE) | 1991-01-29 | — | — | US | disclosed |
| US-4920225-A | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1990-04-24 | — | — | US | disclosed |
| US-4849433-A | The compound, (⃡)1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarboxylic acid, methyl isobutyl ester, compositions containing same and a method for effecting coronary dilation | BAYER AKTIENGESELLSCHAFT (DE) | 1989-07-18 | — | — | US | disclosed |
| EP-0273349-A2 | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1988-07-06 | — | — | EP | disclosed |
| US-4510310-A | 1,4-Dihydro-2,6-dimethyl-4-(2'-chlorophenyl)-3,5-dicarboxylic acid,methyl or ethyl,trifluoroethyl ester | BAYER AKTIENGESELLSCHAFT (DE) | 1985-04-09 | — | — | US | disclosed |