Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GID4 | Q8IVV7 | 2/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266112 | 1.00 | GID4 (0.51) | GID4IDO1HTR2BPOLBPKM | |
| SCHEMBL10177547 | 0.85 | IDO1 (0.54) | GID4IDO1HTR2BPOLBPKM | |
| SCHEMBL2276872 | 0.83 | ALDH1A1 (0.59) | GID4IDO1HTR2BPOLBPKM | |
| Hydrochloric Acid SCHEMBL31596380 | 0.82 | MAPT (0.57) | GID4HTR2BPOLBPKMMAPT | |
| SCHEMBL5024041 | 0.81 | IDO1 (0.52) | GID4IDO1HTR2BPOLBPKM | |
| SCHEMBL5024044 | 0.81 | IDO1 (0.52) | GID4IDO1HTR2BPOLBPKM | |
| SCHEMBL6753945 | 0.79 | TRPC3 (0.55) | GID4HTR2BPOLBPKMMAPT | |
| Ammonia Solution, Strong SCHEMBL5028354 | 0.78 | TRPC3 (0.54) | GID4HTR2BPOLBPKMMAPT | |
| SCHEMBL2640300 | 0.78 | PARP1 (0.56) | GID4HTR2BPOLBPKMMAPT | |
| SCHEMBL10539462 | 0.77 | HTR2B (0.51) | GID4IDO1HTR2BPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268148-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |
| US-4808605-A | Tetrahydronaphthalene derivatives as calcium antagonists | HOFFMANN-LA ROCHE INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0268148-A1 | Tetrahydronaphthalene derivatives and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-05-25 | — | — | EP | disclosed |