Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 6/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.49 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | THPO | P40225 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265309 | 0.87 | CACNA1C (0.51) | CACNA1CCACNA1FCACNA1DCACNA1SCACNA1B | |
| SCHEMBL10564440 | 0.86 | CACNA1F (0.61) | CACNA1CCACNA1FCACNA1DCACNA1SCACNA1B | |
| SCHEMBL28762620 | 0.85 | CACNA1B (0.51) | CACNA1CCACNA1FCACNA1DCACNA1SCACNA1B | |
| SCHEMBL7272316 | 0.84 | CACNA1F (0.62) | CACNA1CCACNA1FCACNA1DCACNA1SCACNA1B | |
| SCHEMBL9617833 | 0.84 | CACNA1F (0.62) | CACNA1CCACNA1FCACNA1DCACNA1SCACNA1B | |
| SCHEMBL27763855 | 0.84 | CYP3A4 (0.41) | CACNA1CCACNA1FCACNA1DCACNA1SCACNA1B | |
| SCHEMBL27286151 | 0.84 | MAPT (0.55) | CACNA1CCACNA1FCACNA1DCACNA1SCACNA1B | |
| SCHEMBL7272376 | 0.83 | CACNA1B (0.53) | CACNA1CCACNA1FCACNA1DCACNA1SCACNA1B | |
| SCHEMBL7275646 | 0.81 | CACNA1F (0.71) | CACNA1CCACNA1FCACNA1DCACNA1SCACNA1B | |
| SCHEMBL7273432 | 0.81 | CACNA1C (0.48) | CACNA1CCACNA1FCACNA1DCACNA1SCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920225-A | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1990-04-24 | — | — | US | disclosed |
| EP-0273349-A2 | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1988-07-06 | — | — | EP | disclosed |