Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 13/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11121066 | 0.86 | KDM4E (0.47) | ROCK2KDM4E | |
| Hydrochloric Acid SCHEMBL7267342 | 0.85 | KDM4E (0.47) | ROCK2KDM4E | |
| SCHEMBL7610256 | 0.82 | ALDH1A1 (0.42) | DPP4DPP8ROCK2KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL3847558 | 0.81 | ALDH1A1 (0.42) | DPP4DPP8ROCK2KMT2AALDH1A1 | |
| SCHEMBL8535632 | 0.81 | DPP4 (0.54) | DPP4DPP8ANPEP | |
| SCHEMBL8393442 | 0.81 | DPP4 (0.54) | DPP4DPP8ANPEP | |
| Hydrochloric Acid SCHEMBL27541624 | 0.80 | DPP4 (0.54) | DPP4DPP8ANPEPPREP | |
| SCHEMBL1006699 | 0.76 | DPP8 (0.47) | DPP4DPP8 | |
| SCHEMBL9643299 | 0.72 | AAK1 (0.50) | ROCK2KDM4E | |
| SCHEMBL4614497 | 0.72 | AAK1 (0.50) | ROCK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613879-B1 | Of given formula; produrg which can be converted to a drug by fibroblast activation protein (FAP); cytotoxic; antiproliferative and anticarcinogenic agent | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-09-02 | — | — | US | disclosed |
| EP-1180116-A2 | FAP-ACTIVATED ANTI-TUMOR COMPOUNDS | Boehringer Ingelheim Pharma KG (DE) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000071571-A2 | FAP-ACTIVATED ANTI-TUMOR COMPOUNDS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-11-30 | — | — | WO | disclosed |