SCHEMBL9643299

SCHEMBL9643299

COc1cc(NC(=O)C2CCCN2)cc2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AAK1 Q2M2I8 1/20 0.50
KDM4E B2RXH2 1/20 0.49
SUV39H2 Q9H5I1 2/20 0.47
KHK P50053 1/20 0.45
ROCK2 O75116 2/20 0.43
PSMB8 P28062 2/20 0.43
ULK1 O75385 1/20 0.43
SCN9A Q15858 2/20 0.42
PFKFB3 Q16875 3/20 0.42
PFKFB2 O60825 2/20 0.42
PFKFB1 P16118 2/20 0.42
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C19 P33261 1/20 0.41
SCN3A Q9NY46 1/20 0.41
SCN5A Q14524 1/20 0.41
HTR2C P28335 1/20 0.40
HTR2B P41595 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4614497 1.00 AAK1 (0.50) AAK1KDM4ESUV39H2KHKROCK2
SCHEMBL11121066 0.82 KDM4E (0.47) AAK1KDM4ESUV39H2ROCK2CYP1A2
Hydrochloric Acid SCHEMBL7267342 0.81 KDM4E (0.47) AAK1KDM4ESUV39H2ROCK2CYP1A2
SCHEMBL7517031 0.81 KDM4E (0.50) AAK1KDM4ESUV39H2KHKROCK2
SCHEMBL15941829 0.79 AAK1 (0.59) AAK1KDM4ESUV39H2KHKPSMB8
SCHEMBL15941391 0.79 AAK1 (0.59) AAK1KDM4ESUV39H2KHKPSMB8
SCHEMBL2293435 0.78 CYP1A2 (0.58) KHKPSMB8ULK1SCN9APFKFB3
SCHEMBL17676985 0.78 ROCK2 (0.50) KHKROCK2PSMB8ULK1HTR2C
SCHEMBL10913060 0.78 CYP1A2 (0.58) KHKPSMB8ULK1SCN9APFKFB3
SCHEMBL29757656 0.78 CYP1A2 (0.58) KHKPSMB8ULK1SCN9APFKFB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5089394-A Neisseria detection system E-Y LABORATORIES, INC. (US) 1992-02-18 US disclosed