Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275870 | 0.85 | CACNA1B (0.38) | ALDH1A1KDM4ETSHRSMN1; SMN2ABCC1 | |
| SCHEMBL7267115 | 0.82 | CACNA1B (0.37) | ALDH1A1KDM4ETSHRSMN1; SMN2ABCC1 | |
| SCHEMBL7267442 | 0.81 | CACNA1B (0.53) | CACNA1B | |
| SCHEMBL27541931 | 0.80 | CACNA1B (0.49) | ALDH1A1KDM4ETSHRSMN1; SMN2ABCC1 | |
| SCHEMBL7267660 | 0.78 | CACNA1F (0.48) | CACNA1BADORA3CACNA1D | |
| SCHEMBL7272327 | 0.78 | CACNA1F (0.60) | TSHRCACNA1BLMNAADORA3MEN1 | |
| SCHEMBL7266744 | 0.78 | CACNA1F (0.48) | SMN1; SMN2CACNA1BLMNAADORA3CACNA1D | |
| SCHEMBL7275522 | 0.78 | TSHR (0.41) | ALDH1A1KDM4ETSHRHPGDHSD17B10 | |
| SCHEMBL7275738 | 0.76 | TSHR (0.52) | ALDH1A1KDM4ETSHRCACNA1BHPGD | |
| SCHEMBL7272429 | 0.76 | CACNA1B (0.41) | CACNA1BADORA3CACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920225-A | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1990-04-24 | — | — | US | disclosed |
| EP-0273349-A2 | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1988-07-06 | — | — | EP | disclosed |