Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 5/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.35 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275870 | 0.85 | CACNA1B (0.38) | CACNA1BCACNA1DKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7272104 | 0.82 | CACNA1B (0.53) | CACNA1B | |
| SCHEMBL7267403 | 0.82 | ALDH1A1 (0.40) | CACNA1BCACNA1DKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL27541931 | 0.80 | CACNA1B (0.49) | CACNA1BCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7267535 | 0.79 | CACNA1F (0.52) | CACNA1BCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7265666 | 0.79 | CACNA1F (0.52) | CACNA1BCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7272545 | 0.79 | CACNA1F (0.55) | CACNA1BCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7267336 | 0.78 | ALOX15 (0.40) | CACNA1BKDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL7272282 | 0.77 | CACNA1F (0.42) | CACNA1BCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7266137 | 0.76 | CYP2C9 (0.47) | CACNA1BCACNA1FCACNA1DCACNA1SCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920225-A | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1990-04-24 | — | — | US | disclosed |
| EP-0273349-A2 | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1988-07-06 | — | — | EP | disclosed |