Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 1/20 | 0.70 |
| ▸ | CTSK | P43235 | 7/20 | 0.67 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.64 |
| ▸ | CTSL | P07711 | 3/20 | 0.64 |
| ▸ | CTSB | P07858 | 3/20 | 0.64 |
| ▸ | CTSS | P25774 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27429302 | 0.91 | PSMB1 (0.67) | PSMB1CTSKCAPN1CTSLCTSB | |
| SCHEMBL27533999 | 0.91 | CTSK (0.70) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL4424261 | 0.91 | CTSK (0.70) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL25406813 | 0.91 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL20770085 | 0.91 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL2930262 | 0.91 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL8823918 | 0.91 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL4872585 | 0.91 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL11124167 | 0.91 | MME (0.64) | PSMB1CTSKCTSLCTSBCTSS | |
| SCHEMBL14148467 | 0.91 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652369-A | PROTEASE INHIBITOR | HOFFMANN-LA ROCHE INC. (US) | 1997-07-29 | — | — | US | disclosed |
| US-5620987-A | Amino acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1997-04-15 | — | — | US | disclosed |
| US-5554756-A | PROTEASE INHIBITOR | HOFFMANN-LA ROCHE INC. (US) | 1996-09-10 | — | — | US | disclosed |
| US-5446161-A | Protease inhibitor, viricides | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| EP-0346847-B1 | Amino acid derivatives | HOFFMANN LA ROCHE (CH) | 1994-05-11 | — | — | EP | disclosed |
| US-5157041-A | Viricides | HOFFMANN-LA ROCHE INC. (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0346847-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-12-20 | — | — | EP | disclosed |