Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.48 |
| ▸ | PDE4A | P27815 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.47 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7268049 | 0.80 | PDE3B (0.50) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL19248285 | 0.72 | PDE3B (0.56) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL17789572 | 0.71 | PDE3B (0.58) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL10353457 | 0.71 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7307403 | 0.69 | PDE3B (0.50) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL6650784 | 0.69 | PDE3B (0.59) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL10016799 | 0.69 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL8342501 | 0.69 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10553519 | 0.69 | PDE3B (0.54) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7276740 | 0.69 | PDE3B (0.64) | PDE3BPDE3AGPR119PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0326307-B1 | Novel pyridazinone derivatives and pharmaceutical preparations containing them | KYOWA HAKKO KOGYO KK (JP) | 1994-08-17 | — | — | EP | disclosed |
| US-5063227-A | QUINAZOLINE-SUBSTITUTED PYRIDAZINONE DERIVATIVES HAVING CARDIOTONIC ACTIVITY | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-11-05 | — | — | US | disclosed |
| EP-0326307-A2 | Novel pyridazinone derivatives and pharmaceutical preparations containing them | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-08-02 | — | — | EP | disclosed |