Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 15/20 | 0.66 |
| ▸ | ITGAV | P06756 | 15/20 | 0.66 |
| ▸ | ITGB5 | P18084 | 5/20 | 0.66 |
| ▸ | ITGB6 | P18564 | 5/20 | 0.66 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5856027 | 0.92 | ITGB3 (0.58) | ITGB3ITGAVITGB5ITGB6ITGA2B | |
| SCHEMBL7172179 | 0.91 | ITGB3 (0.57) | ITGB3ITGAVITGB5ITGB6ITGA2B | |
| SCHEMBL7170034 | 0.88 | ITGB3 (0.54) | ITGB3ITGAVITGB5ITGB6ITGA2B | |
| SCHEMBL30446650 | 0.83 | ITGAV (0.54) | ITGB3ITGAVITGB5ITGB6ITGA2B | |
| SCHEMBL6585073 | 0.83 | ITGB3 (0.51) | ITGB3ITGAVITGB5ITGB6ITGA2B | |
| SCHEMBL7104922 | 0.83 | ITGB3 (0.89) | ITGB3ITGAVITGB5ITGB6ITGA2B | |
| SCHEMBL7039474 | 0.81 | ITGAV (0.57) | ITGB3ITGAVITGB5ITGB6ITGA2B | |
| SCHEMBL7261887 | 0.80 | ITGB3 (0.81) | ITGB3ITGAVITGB5ITGB6ITGA2B | |
| SCHEMBL7262407 | 0.80 | ITGB3 (0.86) | ITGB3ITGAVITGB5ITGB6ITGA2B | |
| SCHEMBL7267221 | 0.80 | ITGB3 (0.86) | ITGB3ITGAVITGB5ITGB6ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649613-B1 | Integrin inhibitors | MERCK PATENT GMBH (DE) | 2003-11-18 | — | — | US | disclosed |