Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369338 | 0.75 | LRRK2 (0.33) | CA12CA1CA2CA9LRRK2 | |
| SCHEMBL27914405 | 0.64 | ALDH1A1 (0.33) | SMN1; SMN2 | |
| SCHEMBL4270863 | 0.63 | LRRK2 (0.36) | LRRK2 | |
| SCHEMBL5157912 | 0.63 | MEN1 (0.36) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL582039 | 0.59 | MEN1 (0.52) | CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL18978083 | 0.57 | SMN1; SMN2 (0.39) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL18978084 | 0.57 | MAPK1 (0.32) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL12936238 | 0.57 | HPGD (0.31) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL20202489 | 0.57 | MEN1 (0.45) | CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL7374475 | 0.55 | HTR2A (0.41) | CA12CA1CA2CA9HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001076693-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-10-18 | — | — | WO | disclosed |
| EP-0541705-A4 | SUBSTITUTED 1H-IMIDAZOL-5-YL)ALKANOIC ACIDS | — | 1993-11-10 | — | — | EP | disclosed |
| EP-0561896-A1 | USE OF ANGIOTENSN II RECEPTOR ANTAGONISTS FOR THE PREPARATION OF A MEDICAMENT FOR IMPROVING COGNITIVE FUNCTION | SMITHKLINE BEECHAM PLC (GB) | 1993-09-29 | — | — | EP | disclosed |
| EP-0541705-A1 | SUBSTITUTED 1H-IMIDAZOL-5-YL]ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-05-19 | — | — | EP | disclosed |
| EP-0425211-A1 | Substituted 5-((tetrazolyl)alkenyl)-imidazoles | SMITHKLINE BEECHAM CORPORATION (US) | 1991-05-02 | — | — | EP | disclosed |
| EP-0403159-A2 | Imidazolyl-alkenoic acids | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-19 | — | — | EP | disclosed |