SCHEMBL7268486

SCHEMBL7268486

Clc1ccc(Cl)c(Sc2cc(Cl)ccc2Cl)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 5/20 0.58
CYP3A4 P08684 5/20 0.58
HSD17B10 Q99714 5/20 0.58
MEN1 O00255 4/20 0.58
KMT2A Q03164 4/20 0.58
ALDH1A1 P00352 4/20 0.58
HTT P42858 3/20 0.58
ALOX15 P16050 3/20 0.58
PLA2G1B P04054 2/20 0.58
ATG4B Q9Y4P1 2/20 0.58
HIF1A Q16665 2/20 0.58
HSP90AA1 P07900 1/20 0.58
CYP2D6 P10635 1/20 0.58
CYP2C9 P11712 1/20 0.58
CYP2C19 P33261 1/20 0.58
RHEB Q15382 1/20 0.55
TP53 P04637 3/20 0.52
KDM4E B2RXH2 2/20 0.50
MAPT P10636 2/20 0.50
ALOX12 P18054 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL224923 0.83 TP53 (0.52) HPGDCYP3A4HSD17B10MEN1KMT2A
SCHEMBL9510742 0.82 MEN1 (0.53) HPGDCYP3A4HSD17B10MEN1KMT2A
SCHEMBL10940318 0.81 TP53 (0.50) HPGDCYP3A4HSD17B10MEN1KMT2A
SCHEMBL19872417 0.79 ALDH1A1 (0.48) HPGDCYP3A4HSD17B10MEN1KMT2A
SCHEMBL27923372 0.79 TP53 (0.48) HPGDCYP3A4HSD17B10MEN1KMT2A
SCHEMBL1145555 0.79 TP53 (0.48) HPGDCYP3A4HSD17B10MEN1KMT2A
SCHEMBL1145559 0.79 TP53 (0.48) HPGDCYP3A4HSD17B10MEN1KMT2A
SCHEMBL8533569 0.79 HPGD (0.68) HPGDCYP3A4HSD17B10MEN1KMT2A
SCHEMBL10537555 0.79 MEN1 (0.55) HPGDCYP3A4HSD17B10MEN1KMT2A
SCHEMBL9630040 0.79 PDE7A (0.61) HPGDCYP3A4HSD17B10MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6558276-B1 Improved feeling without impairing intrinsic resilience; core made from rubber composition of a base rubber, an organic peroxide, an alpha, beta unsaturated carboxylic acid, and a bis type halogen-substituted phenyl disulfide SUMITOMO RUBBER INDUSTRIES LIMITED (JP) 2003-05-06 US disclosed
US-6241625-B1 A GOLF BALL COMPRISING A COVER MEMBER AND A CORE MEMBER, WHEREIN POLYAMIDE, TERPOLYMER IONOMER CONTAINING ETHYLENE, (METH)ACRYLIC ACID, AND (METH)ACRYLIC ESTER MIXTURES WITH PEROXIDE AND SULFIDE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2001-06-05 US disclosed
US-5250657-A Process for preparing polyarylene thioether SEISAN KAIHATSU KAGAKU KENKYUSHO (JP) 1993-10-05 US disclosed
EP-0440106-A2 Process for preparing polyarylene thioethers SEISAN KAIHATSU KAGAKU KENKYUSHO (JP) 1991-08-07 EP disclosed