Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653269 | 0.79 | GAA (0.57) | NR3C1GAASIGMAR1CYP2D6TSHR | |
| SCHEMBL4369263 | 0.77 | GAA (0.50) | NR3C1GAASIGMAR1CYP2D6TSHR | |
| SCHEMBL3315042 | 0.76 | NR3C1 (0.49) | NR3C1GAASIGMAR1CYP2D6MEN1 | |
| SCHEMBL13090069 | 0.76 | NR3C1 (0.52) | NR3C1GAASIGMAR1CYP2D6ALDH1A1 | |
| SCHEMBL4364213 | 0.75 | GAA (0.53) | NR3C1GAASIGMAR1CYP2D6TSHR | |
| SCHEMBL6583420 | 0.75 | NR3C1 (0.44) | NR3C1GAASIGMAR1CYP2D6ALDH1A1 | |
| SCHEMBL6581527 | 0.74 | GAA (0.51) | NR3C1GAASIGMAR1CYP2D6ALDH1A1 | |
| SCHEMBL21465773 | 0.74 | CYP2D6 (0.46) | NR3C1GAACYP2D6ALDH1A1TSHR | |
| SCHEMBL1618300 | 0.74 | NR3C1 (0.48) | NR3C1GAACYP2D6ALDH1A1TSHR | |
| SCHEMBL6582036 | 0.74 | NR3C1 (0.47) | NR3C1GAASIGMAR1CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421867-A2 | PIPERIDINE INHIBITORS OF JANUS KINASE 3 | Auspex Pharmaceuticals, Llc (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010123919-A2 | PIPERIDINE INHIBITORS OF JANUS KINASE 3 | AUSPEX PHARMACEUTICALS, LLC (US) | 2010-10-28 | — | — | WO | disclosed |