Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.34 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269588 | 1.00 | ADAM17 (0.36) | ADAM17ALOX12ALOX15HSPA5HSPA2 | |
| SCHEMBL7270075 | 1.00 | ADAM17 (0.36) | ADAM17ALOX12ALOX15HSPA5HSPA2 | |
| SCHEMBL7269596 | 1.00 | ADAM17 (0.36) | ADAM17ALOX12ALOX15HSPA5HSPA2 | |
| SCHEMBL7269591 | 1.00 | ADAM17 (0.36) | ADAM17ALOX12ALOX15HSPA5HSPA2 | |
| SCHEMBL15676387 | 0.83 | ADAM17 (0.38) | ADAM17ALOX12ALOX15HSPA5ALDH1A1 | |
| SCHEMBL15676401 | 0.80 | ALDH1A1 (0.38) | ADAM17ALOX12ALOX15MAPKAPK2ALDH1A1 | |
| SCHEMBL15676022 | 0.80 | ALDH1A1 (0.38) | ADAM17ALOX12ALOX15MAPKAPK2ALDH1A1 | |
| SCHEMBL15676503 | 0.80 | ALDH1A1 (0.38) | ADAM17ALOX12ALOX15MAPKAPK2ALDH1A1 | |
| SCHEMBL14151615 | 0.79 | AAK1 (0.38) | ALOX12ALOX15HSPA5HSPA2FFAR2 | |
| SCHEMBL14152740 | 0.79 | AAK1 (0.38) | ALOX12ALOX15HSPA5HSPA2FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5106835-A | Hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-04-21 | — | — | US | disclosed |
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |
| EP-0376012-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |