Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.46 |
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275074 | 0.91 | HTR1A (0.52) | GRIN2BSLC6A4HTR1ASLC6A2SLC6A3 | |
| SCHEMBL7269770 | 0.87 | PDE3B (0.61) | SLC6A4HTR1ASLC6A2SLC6A3KCNH2 | |
| SCHEMBL7278365 | 0.80 | KCNH2 (0.51) | GRIN2BSLC6A4HTR1ASLC6A2SLC6A3 | |
| SCHEMBL7267716 | 0.80 | SLC6A4 (0.49) | SLC6A4HTR1ASLC6A2SLC6A3KCNH2 | |
| SCHEMBL10837837 | 0.79 | MAPT (0.62) | GRIN2BSLC6A4HTR1AKCNH2NR3C1 | |
| SCHEMBL7268230 | 0.79 | HTR1A (0.46) | GRIN2BSLC6A4HTR1ASLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL11255645 | 0.76 | GRIN2B (0.57) | GRIN2BHTR1ADRD4HTR2AHTR7 | |
| SCHEMBL7344494 | 0.76 | GRIN2B (0.57) | GRIN2BSLC6A4HTR1AKCNH2NR3C1 | |
| Hydrochloric Acid SCHEMBL10838416 | 0.74 | GRIN2B (0.55) | GRIN2BHTR1ADRD4HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL7349822 | 0.74 | GRIN2B (0.55) | GRIN2BSLC6A4HTR1AKCNH2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0370381-B1 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-4988698-A | Cardiovascular disorders, hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-29 | — | — | US | disclosed |
| EP-0370381-A2 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-30 | — | — | EP | disclosed |