Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269188 | 0.91 | GRIN2B (0.47) | HTR1ADRD3DRD4HTR2AHTR7 | |
| SCHEMBL7269770 | 0.85 | PDE3B (0.61) | HTR1ASLC6A4SLC6A2SLC6A3NR3C1 | |
| SCHEMBL10837493 | 0.81 | HTR1A (0.65) | HTR1ADRD3DRD4HTR2AHTR7 | |
| SCHEMBL7268230 | 0.81 | HTR1A (0.46) | HTR1ADRD4HTR2ASLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL10836120 | 0.81 | HTR1A (0.57) | HTR1ADRD3DRD4HTR2AHTR7 | |
| SCHEMBL10836042 | 0.79 | DRD3 (0.58) | HTR1ADRD3DRD4HTR2AHTR7 | |
| SCHEMBL10836062 | 0.79 | HTR1A (0.55) | HTR1ADRD3DRD4HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL10837678 | 0.79 | HTR1A (0.58) | HTR1ADRD3DRD4HTR2AHTR7 | |
| SCHEMBL7278365 | 0.79 | KCNH2 (0.51) | HTR1AHTR2AHTR7SLC6A4SLC6A2 | |
| SCHEMBL7267716 | 0.79 | SLC6A4 (0.49) | HTR1ASLC6A4SLC6A2SLC6A3NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0370381-B1 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-4988698-A | Cardiovascular disorders, hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-29 | — | — | US | disclosed |
| EP-0370381-A2 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-30 | — | — | EP | disclosed |