Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NAAA | Q02083 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1014753 | 0.87 | NPC1 (0.66) | MAPK1NPC1RAB9ANAAAHDAC3 | |
| SCHEMBL10363539 | 0.86 | MAPK1 (0.72) | MAPK1ALDH1A1NPC1RAB9ANAAA | |
| SCHEMBL5612077 | 0.84 | DRD2 (0.64) | NPC1RAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL10173739 | 0.81 | NAAA (0.67) | MAPK1ALDH1A1NPC1RAB9ANAAA | |
| SCHEMBL16557239 | 0.81 | POLB (0.68) | MAPK1ALDH1A1NPC1RAB9ANAAA | |
| SCHEMBL1556347 | 0.81 | HDAC1 (0.67) | MAPK1ALDH1A1NPC1RAB9ANAAA | |
| SCHEMBL27447913 | 0.81 | EPHX2 (0.49) | MAPK1ALDH1A1NPC1RAB9AHDAC1 | |
| SCHEMBL8353635 | 0.80 | MAPK1 (0.59) | MAPK1ALDH1A1NPC1RAB9ANAAA | |
| SCHEMBL5097388 | 0.80 | NAAA (0.66) | ALDH1A1NPC1RAB9ANAAAHDAC2 | |
| SCHEMBL1416823 | 0.80 | HDAC1 (0.70) | MAPK1ALDH1A1NPC1RAB9ANAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236872-B1 | HYDROXYL AMINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-25 | — | — | EP | claimed |
| US-4996358-A | Control, prevention rheumatic diseases | HOFFMANN-LA ROCHE INC. (US) | 1991-02-26 | — | — | US | claimed |
| EP-0236872-A2 | Hydroxyl amine derivatives, their preparation and use as medicaments | F. HOFFMANN-LA ROCHE AG (CH) | 1987-09-16 | — | — | EP | claimed |
| EP-0236872-B1 | HYDROXYL AMINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-25 | — | — | EP | disclosed |
| EP-0423943-A2 | Use of collagenase inhibitors in the treatment of demyelinating diseases, in particular multiple sclerosis | Beecham Group p.l.c. (GB) | 1991-04-24 | — | — | EP | disclosed |
| US-4996358-A | Control, prevention rheumatic diseases | HOFFMANN-LA ROCHE INC. (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0236872-A2 | Hydroxyl amine derivatives, their preparation and use as medicaments | F. HOFFMANN-LA ROCHE AG (CH) | 1987-09-16 | — | — | EP | disclosed |