Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5753754 | 0.98 | CYP2A6 (0.41) | HTR3BADRA2AKCNE1ADRA2CCHRM3 | |
| SCHEMBL5750856 | 0.72 | LMNA (0.36) | LMNASMN1; SMN2PTGS1PTGS2CES1 | |
| SCHEMBL4847795 | 0.71 | MAPT (0.40) | HTR3BADRA2AKCNE1ADRA2CCHRM3 | |
| SCHEMBL829382 | 0.70 | HTR3B (0.50) | HTR3BADRA2AKCNE1ADRA2CCHRM3 | |
| SCHEMBL11524815 | 0.70 | HTR3B (0.47) | HTR3BADRA2AKCNE1ADRA2CCHRM3 | |
| SCHEMBL651409 | 0.69 | HTR3B (0.38) | HTR3BADRA2AKCNE1ADRA2CCHRM3 | |
| SCHEMBL829845 | 0.68 | TSHR (0.48) | HTR3BADRA2AKCNE1ADRA2CCHRM3 | |
| SCHEMBL14084703 | 0.67 | ALOX15 (0.37) | MAOBLMNAPARP1SMN1; SMN2PTGS1 | |
| SCHEMBL6744036 | 0.65 | CYP2A6 (0.43) | CYP2A6MAOAMAOBLMNAPARP1 | |
| SCHEMBL4846404 | 0.65 | MAPT (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430190-B1 | New tricyclic compounds | SYNTEX INC (US) | 1995-07-05 | — | — | EP | disclosed |
| US-5202333-A | Tricyclic 5-HT3 receptor antagonists | SYNTEX (U.S.A.) INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0430190-A2 | New tricyclic compounds | SYNTEX (U.S.A.) INC. (US) | 1991-06-05 | — | — | EP | disclosed |