Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046549 | 0.74 | ALDH1A1 (0.57) | RAB9ANPC1L3MBTL1HPGDALDH1A1 | |
| SCHEMBL6414100 | 0.72 | RAB9A (0.55) | RAB9ANPC1L3MBTL1HPGDALDH1A1 | |
| SCHEMBL7260704 | 0.68 | RAB9A (0.51) | RAB9ANPC1L3MBTL1HPGDALDH1A1 | |
| SCHEMBL24577735 | 0.68 | DAO (0.64) | RAB9ANPC1HPGDALDH1A1MEN1 | |
| SCHEMBL25334439 | 0.68 | DAO (0.64) | RAB9ANPC1HPGDALDH1A1MEN1 | |
| SCHEMBL12262036 | 0.67 | ALDH1A1 (0.60) | RAB9ANPC1L3MBTL1HPGDALDH1A1 | |
| Thiophene Carboxylic Acid SCHEMBL27808722 | 0.67 | DAO (0.63) | RAB9ANPC1L3MBTL1HPGDALDH1A1 | |
| SCHEMBL28024080 | 0.67 | RAB9A (0.55) | RAB9ANPC1L3MBTL1HPGDALDH1A1 | |
| SCHEMBL28194803 | 0.67 | HPGD (0.44) | RAB9ANPC1L3MBTL1HPGDALDH1A1 | |
| SCHEMBL9049027 | 0.66 | RAB9A (0.58) | RAB9ANPC1L3MBTL1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5189023-A | Hypotensive agent | AMERICAN CYANAMID COMPANY (US) | 1993-02-23 | — | — | US | disclosed |
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0473936-A1 | Renin Inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-03-11 | — | — | EP | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |