Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 9/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.45 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.44 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.44 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331710 | 0.91 | ABCC9 (0.58) | ABCC9KDM4EABCB1KCNE1KCNQ1 | |
| SCHEMBL7355171 | 0.90 | ABCC9 (0.46) | ABCC9KDM4EABCB1KCNE1KCNQ1 | |
| SCHEMBL7333125 | 0.89 | ABCC9 (0.56) | ABCC9KDM4EABCB1KCNE1KCNQ1 | |
| SCHEMBL7331226 | 0.86 | ABCC9 (0.46) | ABCC9KDM4EABCB1KCNE1KCNQ1 | |
| SCHEMBL7357760 | 0.85 | ABCC9 (0.43) | ABCC9KDM4EABCB1KCNE1KCNQ1 | |
| SCHEMBL482450 | 0.85 | ABCC9 (0.57) | ABCC9KDM4EABCB1CYP3A4 | |
| SCHEMBL13079599 | 0.85 | ABCC9 (0.57) | ABCC9KDM4EABCB1CYP3A4 | |
| SCHEMBL7364124 | 0.84 | ABCC9 (0.41) | ABCC9KDM4EABCB1KCNE1KCNQ1 | |
| SCHEMBL7360393 | 0.84 | ABCC9 (0.58) | ABCC9KDM4EABCB1KCNE1KCNQ1 | |
| SCHEMBL8088840 | 0.84 | ABCC9 (0.56) | ABCC9KDM4EABCB1KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | claimed |
| EP-0363883-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1990-04-18 | — | — | EP | claimed |
| EP-0346724-A1 | Chroman derivates | MERCK PATENT GmbH (DE) | 1989-12-20 | — | — | EP | claimed |
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0442141-B1 | Pharmaceutical preparation | MERCK PATENT GMBH (DE) | 1994-03-02 | — | — | EP | disclosed |
| EP-0561357-A1 | Pharmaceutical composition comprising a potassium-channel-opener and an antagonist of angiotensin-II receptors | MERCK PATENT GmbH (DE) | 1993-09-22 | — | — | EP | disclosed |
| EP-0442141-A1 | Pharmaceutical preparation | MERCK PATENT GmbH (DE) | 1991-08-21 | — | — | EP | disclosed |
| EP-0401505-A2 | Pharmaceutical composition containing a potassium channel-activator and an ace-inhibitor | MERCK PATENT GmbH (DE) | 1990-12-12 | — | — | EP | disclosed |
| EP-0363883-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1990-04-18 | — | — | EP | disclosed |
| EP-0346724-A1 | Chroman derivates | MERCK PATENT GmbH (DE) | 1989-12-20 | — | — | EP | disclosed |