SCHEMBL7269608

SCHEMBL7269608

CN1Cc2c(CO)ncn2-c2ccccc2C1=O

nearest known ligand 0.65

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GABRG2 P18507 7/20 0.61
GABRB3 P28472 7/20 0.61
GABRA5 P31644 7/20 0.61
GABRA1 P14867 5/20 0.61
GABRA3 P34903 5/20 0.61
GABRA2 P47869 5/20 0.61
GABRA6 Q16445 4/20 0.56
GABRA4 P48169 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10964002 0.88 GABRG2 (0.72) GABRG2GABRB3GABRA5GABRA1GABRA3
SCHEMBL10964635 0.87 GABRG2 (0.72) GABRG2GABRB3GABRA5GABRA1GABRA3
SCHEMBL13321573 0.84 GABRG2 (0.61) GABRG2GABRB3GABRA5GABRA1GABRA3
SCHEMBL8235515 0.83 GABRG2 (0.81) GABRG2GABRB3GABRA5GABRA1GABRA3
SCHEMBL11217198 0.83 GABRG2 (0.64) GABRG2GABRB3GABRA5GABRA1GABRA3
SCHEMBL11233075 0.81 GABRG2 (0.63) GABRG2GABRB3GABRA5GABRA1GABRA3
SCHEMBL10625644 0.81 GABRG2 (0.61) GABRG2GABRB3GABRA5GABRA1GABRA3
SCHEMBL9670393 0.80 GABRG2 (0.59) GABRG2GABRB3GABRA5GABRA1GABRA3
SCHEMBL10963477 0.80 GABRG2 (0.59) GABRG2GABRB3GABRA5GABRA1GABRA3
SCHEMBL9869532 0.80 GABRG2 (0.59) GABRG2GABRB3GABRA5GABRA1GABRA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0285837-B1 IMIDAZODIAZEPIN DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1992-07-08 EP disclosed
US-4863920-A SEDATIVES, TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1989-09-05 US disclosed
EP-0285837-A1 Imidazodiazepin derivatives F. HOFFMANN-LA ROCHE AG (CH) 1988-10-12 EP disclosed
EP-0059390-B1 IMIDAZODIAZEPINES, INTERMEDIATE PRODUCTS AND PROCESS FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1985-05-29 EP disclosed
US-4363762-A Process for preparing imidazodiazepines HOFFMANN-LA ROCHE INC. (US) 1982-12-14 US disclosed
US-4359420-A HYPOTENSIVE AGENT, MUSCLE RELAXANTS HOFFMANN-LA ROCHE INC. (US) 1982-11-16 US disclosed
US-4352818-A ANTIDOTES FOR INTOXICATION CAUSED BY 1,4-BENZODIAZEPINE TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1982-10-05 US disclosed
EP-0059390-A1 Imidazodiazepines, intermediate products and process for their preparation, and medicines containing them F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1982-09-08 EP disclosed
US-4346034-A Process for preparing imidazodiazepines HOFFMANN-LA ROCHE INC. (US) 1982-08-24 US disclosed
US-4346032-A ANTIDOTES TO OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1982-08-24 US disclosed
US-4346030-A ANTIDOTES FOR OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1982-08-24 US disclosed
US-4346035-A Process for preparing imidazodiazepines HOFFMANN-LA ROCHE INC. (US) 1982-08-24 US disclosed
US-4346031-A Process for preparing imidazodiazepines HOFFMANN-LA ROCHE INC. (US) 1982-08-24 US disclosed
US-4346036-A ALKYLATION; AMIDATION; TRANQUILIZER ANTAGONIST HOFFMANN-LA ROCHE INC. (US) 1982-08-24 US disclosed
US-4346033-A Thienodiazepinone and benzodiazepinone intermediates HOFFMANN-LA ROCHE INC. (US) 1982-08-24 US disclosed
US-4316839-A Imidazodiazepine derivatives HOFFMAN-LA ROCHE INC. (US) 1982-02-23 US disclosed
EP-0027214-A1 Imidazodiazepine derivatives, process and intermediates for their preparation, medicaments containing them and their therapeutic application F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1981-04-22 EP disclosed