Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 7/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.59 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.59 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.59 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.47 |
| ▸ | GABRP | O00591 | 1/20 | 0.47 |
| ▸ | GABRD | O14764 | 1/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | GABRE | P78334 | 1/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11233075 | 0.84 | GABRG2 (0.63) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9869532 | 0.83 | GABRG2 (0.59) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10962822 | 0.83 | GABRG2 (0.59) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10965417 | 0.83 | GABRG2 (0.59) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10963477 | 0.83 | GABRG2 (0.59) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL20286363 | 0.83 | GABRG2 (0.54) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10963571 | 0.82 | GABRG2 (0.63) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7271413 | 0.81 | GABRG2 (0.57) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7278640 | 0.80 | GABRA1 (0.71) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7279375 | 0.80 | GABRG2 (0.56) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0059390-B1 | IMIDAZODIAZEPINES, INTERMEDIATE PRODUCTS AND PROCESS FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-29 | — | — | EP | claimed |
| US-4352818-A | ANTIDOTES FOR INTOXICATION CAUSED BY 1,4-BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-10-05 | — | — | US | claimed |
| EP-0285837-B1 | IMIDAZODIAZEPIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-07-08 | — | — | EP | disclosed |
| US-4863920-A | SEDATIVES, TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0059390-B1 | IMIDAZODIAZEPINES, INTERMEDIATE PRODUCTS AND PROCESS FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-29 | — | — | EP | disclosed |
| US-4352818-A | ANTIDOTES FOR INTOXICATION CAUSED BY 1,4-BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-10-05 | — | — | US | disclosed |
| EP-0059390-A1 | Imidazodiazepines, intermediate products and process for their preparation, and medicines containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-08 | — | — | EP | disclosed |